OTC Medications During Pregnancy

Evidence-based guidance on which OTC medications are considered safe during pregnancy and which to avoid, organized by symptom and trimester.

Generally Considered Safe in Pregnancy

Acetaminophen for pain and fever (preferred over NSAIDs)
Certain antacids: calcium carbonate, magnesium hydroxide (avoid bicarbonate-based)
Loratadine or cetirizine for allergies (first-generation antihistamines with caution)
Vitamin B6 and doxylamine for nausea (first-line recommendation)

Generally Avoid During Pregnancy

NSAIDs (ibuprofen, naproxen, aspirin) especially in third trimester
Decongestants in first trimester
High-dose vitamins beyond prenatal recommendations